Causes of Chylomicronaemia The chylomicronaemia syndrome occasionally occurs when LPL is inactive as a result of a genetic defect in the enzyme or its cofactor, apo CII. Much more commonly, it is due to saturation of the capacity of LPL to remove triglyceride, a result of the coexistence of a genetic form of hypertriglyceridaemia with a disorder of plasma triglyceride metabolism. The latter may be due to one or more diseases, or to drugs (Fig. 6.28)